�Young men with eccentric 2 diabetes have significantly low levels of testosterone, endocrinologists at the University at Buffalo have base - a condition that could receive a critical effect on their quality of life and on their power to begetter children.
This study follows research published originally by these scientists reporting that tierce of middle-aged men with type 2 diabetes let low testosterone levels, requiring treatment for erectile dysfunction.
"These new findings have respective clinical implications besides the impairment of sexual function in these young men," said Paresh Dandona, Ph.D., UB Distinguished Professor in the Department of Medicine and senior author on both studies.
"The lack of testosterone during these critical years may lead to diminished pearl mass and the lack of evolution or deprivation of skeletal muscle. In addition, these patients may gain more than weight (with an average body mass index of 38 they already were obese) and become more than insulin resistant.
"Also, patients with low testosterone and type 2 diabetes have been shown to have very high concentrations of C reactive protein," he added, "which increases their jeopardy of developing atherosclerosis and heart disease above and beyond the risk associated with diabetes."
Results of the new study appear in the on-line edition of Diabetes Care and testament be published in an upcoming variation of the journal.
Anil Chandel, M.D., UB clinical assistant instructor and medical occupant working with Dandona, is first author.
The current study was conducted in 38 men with type 1 diabetes and 24 manpower with type 2 diabetes who were referred to the Diabetes-Endocrinology Clinic of Western New York at Millard Fillmore Hospital of Kaleida Health, where Dandona is foreman of the Division of Endocrinology.
The average age of men in the type 1 and type 2 groups was 26 and 27, severally, with a range of 18-35 years.
Results showed that type 2 diabetics had half the amount of total and free testosterone in their blood as their type 1 counterparts. Free testosterone is the amount of the endocrine not bound by protein molecules that can sham bodily functions.
Using the amount of free testosterone considered normal in men in general, eight-spot out of the 24 type 2 diabetics had below-normal concentrations. However, exploitation the normal range for men of their age, 14 out of the 24, or 58 percentage of the young type 2 diabetics had lour than normal testosterone levels. Type 1 diabetics, in the meantime, had normal levels of total and free testosterone for their age group.
Patients with below-normal testosterone besides had abject levels of luteinizing hormone (LH) and follicle-stimulating internal secretion (FSH), which are released by the pituitary secreter and ar essential for testosterone secernment and normal fertility. Low levels of all three hormones results in a syndrome known as hypogonadotropic hypogonadism.
"While obesity contributes to the tie of type 2 diabetes and hypogonadotropic hypogonadism (HH), the association is not dependent wholly on corpulency," said Dandona. "In our first written report of diabetic men, we found that 31 percentage of lean type 2 diabetics likewise had HH, so it is probable that factors other than obesity contribute to HH, possibly insulin resistance. Type 2 diabetic patients in the main have higher insulin opposition, while all obese men are not insulin resistant.
"Whether obesity or insulin resistance is the major determinant of HH has to be addressed in future studies, and the pathogenesis of HH needs to be defined," he aforementioned. Dandona's chemical group currently is investigating these questions.
Researchers tortuous in the study in addition to Dandona and Chandel were Sandeep Dhindsa, M.D.; Shehzad Topiwala, M.D.; and Ajay Chaudhuri, M.D., all members of Dandona's research group.
The study was supported by a duncan James Corrow Grant to Dandona from the National Institutes of wellness. The University at Buffalo is a premier research-intensive public university, a flagship institution in the State University of New York system and its largest and to the highest degree comprehensive campus. UB's more than 28,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. The School of Medicine and Biomedical Sciences is one of the 5 schools comprising UB's Academic Health Center. Founded in 1846, the University at Buffalo is a member of the Association of American Universities.
Source: Lois Baker
University at Buffalo
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