�Young men with eccentric 2 diabetes have significantly low levels of testosterone, endocrinologists at the University at Buffalo have base - a condition that could receive a critical effect on their quality of life and on their power to begetter children.
This study follows research published originally by these scientists reporting that tierce of middle-aged men with type 2 diabetes let low testosterone levels, requiring treatment for erectile dysfunction.
"These new findings have respective clinical implications besides the impairment of sexual function in these young men," said Paresh Dandona, Ph.D., UB Distinguished Professor in the Department of Medicine and senior author on both studies.
"The lack of testosterone during these critical years may lead to diminished pearl mass and the lack of evolution or deprivation of skeletal muscle. In addition, these patients may gain more than weight (with an average body mass index of 38 they already were obese) and become more than insulin resistant.
"Also, patients with low testosterone and type 2 diabetes have been shown to have very high concentrations of C reactive protein," he added, "which increases their jeopardy of developing atherosclerosis and heart disease above and beyond the risk associated with diabetes."
Results of the new study appear in the on-line edition of Diabetes Care and testament be published in an upcoming variation of the journal.
Anil Chandel, M.D., UB clinical assistant instructor and medical occupant working with Dandona, is first author.
The current study was conducted in 38 men with type 1 diabetes and 24 manpower with type 2 diabetes who were referred to the Diabetes-Endocrinology Clinic of Western New York at Millard Fillmore Hospital of Kaleida Health, where Dandona is foreman of the Division of Endocrinology.
The average age of men in the type 1 and type 2 groups was 26 and 27, severally, with a range of 18-35 years.
Results showed that type 2 diabetics had half the amount of total and free testosterone in their blood as their type 1 counterparts. Free testosterone is the amount of the endocrine not bound by protein molecules that can sham bodily functions.
Using the amount of free testosterone considered normal in men in general, eight-spot out of the 24 type 2 diabetics had below-normal concentrations. However, exploitation the normal range for men of their age, 14 out of the 24, or 58 percentage of the young type 2 diabetics had lour than normal testosterone levels. Type 1 diabetics, in the meantime, had normal levels of total and free testosterone for their age group.
Patients with below-normal testosterone besides had abject levels of luteinizing hormone (LH) and follicle-stimulating internal secretion (FSH), which are released by the pituitary secreter and ar essential for testosterone secernment and normal fertility. Low levels of all three hormones results in a syndrome known as hypogonadotropic hypogonadism.
"While obesity contributes to the tie of type 2 diabetes and hypogonadotropic hypogonadism (HH), the association is not dependent wholly on corpulency," said Dandona. "In our first written report of diabetic men, we found that 31 percentage of lean type 2 diabetics likewise had HH, so it is probable that factors other than obesity contribute to HH, possibly insulin resistance. Type 2 diabetic patients in the main have higher insulin opposition, while all obese men are not insulin resistant.
"Whether obesity or insulin resistance is the major determinant of HH has to be addressed in future studies, and the pathogenesis of HH needs to be defined," he aforementioned. Dandona's chemical group currently is investigating these questions.
Researchers tortuous in the study in addition to Dandona and Chandel were Sandeep Dhindsa, M.D.; Shehzad Topiwala, M.D.; and Ajay Chaudhuri, M.D., all members of Dandona's research group.
The study was supported by a duncan James Corrow Grant to Dandona from the National Institutes of wellness. The University at Buffalo is a premier research-intensive public university, a flagship institution in the State University of New York system and its largest and to the highest degree comprehensive campus. UB's more than 28,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. The School of Medicine and Biomedical Sciences is one of the 5 schools comprising UB's Academic Health Center. Founded in 1846, the University at Buffalo is a member of the Association of American Universities.
Source: Lois Baker
University at Buffalo
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Tuesday, 2 September 2008
Saturday, 23 August 2008
NPA Responds To Research On The Reported Interactions Between Fruit Juices And Medicines
�The NPA has responded to findings of recent research that implies that consuming apple and orange juice with certain medicines can reduce their effectiveness.
Colette McCreedy, NPA Director of Pharmacy Practice and Chief Pharmacist said: "The result on grapefruit juice on some medicines is well established and where this applies it is intelligibly detailed in Patient Information Leaflets. Pharmacists will ordinarily draw this matter to patients' attention when dispensing their medicines. This new research screening that orchard apple tree and orange juice may enhance or reduce the effects of some medicines is interesting but it is just one study. Usually further research is needed to establish that these interactions are significant."
Colette adds: "We would urge that anybody who is having side effects or has concerns about their medicines asks their pill roller for advice."
National Pharmacy Association
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Colette McCreedy, NPA Director of Pharmacy Practice and Chief Pharmacist said: "The result on grapefruit juice on some medicines is well established and where this applies it is intelligibly detailed in Patient Information Leaflets. Pharmacists will ordinarily draw this matter to patients' attention when dispensing their medicines. This new research screening that orchard apple tree and orange juice may enhance or reduce the effects of some medicines is interesting but it is just one study. Usually further research is needed to establish that these interactions are significant."
Colette adds: "We would urge that anybody who is having side effects or has concerns about their medicines asks their pill roller for advice."
National Pharmacy Association
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Wednesday, 13 August 2008
'South Park' pays tribute to Isaac Hayes
South Park's creators have paid tribute to Isaac Hayes - despite their relationship with the isaac Bashevis Singer ending acrimoniously.
The soul legend died on Sunday (August 10) after apparently suffering a stroke at his home in Memphis.
Hayes supplied the part for the cartoon's grapheme Chef (portrayed), from the show's 1998 inception until 2006, just the programme's creators fell out with him after an episode that featured his religion scientology.
As a outcome of Hayes' departure creators Trey Stone and Matt Parker killed his character off in brutal fashion.
The duette were critical of the singer for being prepared to cooperate in shows attacking early religions only not his own, although it was later suggested that having suffered a stroke scarcely before his departure he was "in no condition to give up anything", and suggested mortal had spoken on his behalf.
However despite the bad blood, the programme has posted a simply "In memoriam" protection featuring Chef on their official site Southparkstudios.com.
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The soul legend died on Sunday (August 10) after apparently suffering a stroke at his home in Memphis.
Hayes supplied the part for the cartoon's grapheme Chef (portrayed), from the show's 1998 inception until 2006, just the programme's creators fell out with him after an episode that featured his religion scientology.
As a outcome of Hayes' departure creators Trey Stone and Matt Parker killed his character off in brutal fashion.
The duette were critical of the singer for being prepared to cooperate in shows attacking early religions only not his own, although it was later suggested that having suffered a stroke scarcely before his departure he was "in no condition to give up anything", and suggested mortal had spoken on his behalf.
However despite the bad blood, the programme has posted a simply "In memoriam" protection featuring Chef on their official site Southparkstudios.com.
More info
Wednesday, 6 August 2008
Health Canada Releases New Report On Climate Change
�The Honourable Tony Clement, Minister of Health, today announced the release of Human Health in a Changing Climate: A Canadian Assessment of Vulnerabilities and Adaptive Capacity.
"Our government takes the issue of climate change very seriously," said Minister Clement. "We are already taking existent action to combat mood change with our Turning the Corner Action Plan to reduce greenhouse
"Our government takes the issue of climate change very seriously," said Minister Clement. "We are already taking existent action to combat mood change with our Turning the Corner Action Plan to reduce greenhouse
Thursday, 26 June 2008
How presidents travel discussed in new book by Richard Ellis
In 1833, President Andrew Jackson was a steamboat passenger when a lieutenant he had once fired asked him if he was, in fact, President Jackson. Jackson allowed as how he was, and was greeted with a punch in the nose.
Early presidents travelled unprotected, and young America liked it that way. The country's love was their protection, we said.
Willamette University Professor Richard Ellis' "Presidential Travel," well-laced with lively anecdotes, is a highly readable look at how presidents wanted to be seen and how Americans wanted to see them, and how travel defined it.
Ellis laments that the topic has been little-explored "because presidential travel provides an important window into the changing relationship between the president and the people." And that relationship may have come full circle - or more.
The Federalist Washington visited each of the 13 colonies in an elegant coach with liveried attendants. Thomas Jefferson rode his own horse with one servant. The popular James Monroe travelled as a private citizen at his own expense.
Americans wanted neither a presidential peacock or a mere stump-speaker, and nothing mildly redolent of Wicked King George, recently trounced and still reviled.
Attitudes changed with the nation.
No. 12, Zachary Taylor, a dusted-off general who shunned offers of private rail cars, was called "Old Zach" by the people who shook his hand through the passenger car window.
Try that today.
For years, some presidents used free passes and palatial coaches provided by happily unregulated railroads.
In the early 1900s, when Theodore Roosevelt travelled across New York City under heavy security, a letter to The New York Times asked if we were "nearing the conditions of monarchy where its crowned head is held in hate by its subjects." And this was after three presidential assassinations in 36 years. It took that much to get mandated federal protection for our head of state.
In 1906, the president finally got his own travel budget, $25,000 a year after eye-gouging partisan squabbling.
Why should he have one? It could be a partial tool. Other Americans didn't have travel budgets. Weren't we all equal?
Well, almost. Congress had had one for decades.
The president needs to travel. But who pays for it?
In 1998, Bill Clinton travelled to six African countries in 12 days for more than $43 million. About 80 per cent was covered by military budgets, the State Department picked up some as did other agencies, with a tiny fraction covered by the executive office.
One study estimates that the government recovered about two per cent of the costs for 46 campaign-related trips taken by George W. Bush in 2002 because they were mingled with less-partisan functions.
This, Ellis writes, was not breaking the law, it was taking advantage of it.
In 1992, Ellis writes, hearings found that in 1990 President Bush had spent $29,000 of his $100,000 allowance for 108 days of travel one year. Ellis says such costs now are "concealed in a baffling array of department and agency budgets." Who pays? Who knows?
Franklin Roosevelt was the first president to fly, often to critical Second World War conferences. But the train took the president to the people.
Between Labour Day and Election Day in 1948 Truman delivered about 250 speeches from the back of a train. Oddly, at its height, the "whistle-stop" campaign gave way to TV and air travel.
By the 1970s, suggestions arose that the "regal presidency" was returning as presidents flew over the United States instead of travelling through it.
New York Times columnist William Safire suggested a "deroyalization" of the presidency. The citizen president, he said, was surrounded "with royal trappings against all propriety and American tradition." Air Force One was a mansion in the sky, with its 85 telephones, seven bathrooms and a luxury suite while millions lacked health insurance.
The president today rolls into select large cities in a motorcade with tinted windows, leaving onlookers unsure of which car he even is in; he often speaks to a screened audience and departs.
Precautions following numerous assassinations and attempts have made the presidency vulnerable to charges that it has lost touch with the people. But the travel is safer and more predictable.
Ellis sees no solution.
"No amount of traveling can break down the barrier now erected between the president and the people," he concludes. "All that is left is spectacle."
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"Presidential Travel. The Journey From George Washington to George W. Bush"
By Richard Ellis (University Press of Kansas)
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Thursday, 19 June 2008
Santogold, Casablancas and Pharrell record track for Converse
There was a time when the most exciting musical projects arose from sheer spontaneity - two or three artists meet at a party, fall in together, and before long we have the Traveling Wilburys or, er, Jackson and McCartney's Say Say Say.
These days the model is different. In 2008, a company, let's say a shoe company, hires a big advertising firm. Executives at the ad firm call their teenage nieces in New York and London, and ask them what's cool. And then the shoe company throws money at people.
That is how we imagine Santogold, the Strokes' Julian Casablancas and Pharrell Williams from the Neptunes came to be working together on a song for Converse trainers. And Santogold - the scattershot American electro-punk who is currently one of the most talked-about artists - is fine with it. "It's like one of the main ways to get our music heard now and so it's stupid for artists to shy away from that," she said to Gigwise.
The new untitled song is "such a Pharrell track", Santogold said. We hope this means it recalls the heights of Justin Timberlake and not the lows of Skateboard P.
A video has also been shot, in which we assume Converse trainers will feature prominently.
Finally, if anyone's worrying that this kind of arbitrary commissioned project might somehow be lacking in a clear, creative vision, Santogold offers the following lucid insight: "Everybody on it does their own separate thing and we didn't do it together so it ends up being just this weird long song with sort of everybody with lots of their own personalities separate."
It's enough to make us long for Michael Jackson and Paul McCartney on a horse-drawn wagon.
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Tuesday, 10 June 2008
'Hannah Montana' film draws music talent
Rascal Flatts, Bucky Covington, Marcel set to appear
Multiplatinum country trio Rascal Flatts will appear and perform in Disney's "Hannah Montana: The Movie," which is filming in Tennessee.
"American Idol" alum Bucky Covington and new artist Marcel also will appear in the film, which is due next year.
Multiplatinum country trio Rascal Flatts will appear and perform in Disney's "Hannah Montana: The Movie," which is filming in Tennessee.
"American Idol" alum Bucky Covington and new artist Marcel also will appear in the film, which is due next year.
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